Insights of OxyR role in mechanisms of host-pathogen interaction of Corynebacterium diphtheriae.

ABSTRACT: Corynebacterium diphtheriae, the leading causing agent of diphtheria, has been increasingly related to invasive diseases, including sepsis, endocarditis, pneumonia, and osteomyelitis. Oxidative stress defense is required not only for successful growth and survival under environmental conditions but also in the regulation of virulence mechanisms of human pathogenic species, by promoting mucosal colonization, survival, dissemination, and defense against the innate immune system. OxyR, functioning as a negative and/or positive transcriptional regulator, has been included among the major bacterial coordinators of antioxidant response. OxyR was first reported as a repressor of catalase expression in C. diphtheriae. However, the involvement of OxyR in C. diphtheriae pathogenesis remains unclear.

SUBMITTER: Cappelli EA 

PROVIDER: S-EPMC9151940 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature