In vivo Illustration of Altered Dopaminergic and GABAergic Systems in Early Parkinson's Disease.

ABSTRACT:

Background

Changes in γ-aminobutyric acid (GABA) function are noted in patients with Parkinson's disease (PD) who have some non-motor impairments. However, dopamine-related GABA function and GABA-related cognitive changes are still unclear.

Methods

Thirteen drug-naive early-stage PD patients underwent a series of PET scans with [¹¹C]flumazenil(FMZ) and [¹¹C]CFT. The [¹¹C]FMZ binding potential (BP_ND) derived from a Logan plot analysis was compared between PD patients and age-matched controls. The [¹¹C]CFT radioactivity relative to the cerebellar counterpart was estimated as a semiquantitative value [¹¹C]CFT SUVR. Correlations between [¹¹C]FMZ BP_ND and [¹¹C]CFT SUVR in the same r

SUBMITTER: Takashima H 

PROVIDER: S-EPMC9152017 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature