The Mesoscopic Connectome of the Cholinergic Pontomesencephalic Tegmentum.

ABSTRACT: The pontomesencephalic tegmentum, comprising the pedunculopontine nucleus and laterodorsal tegmental nucleus, is involved in various functions via complex connections; however, the organizational structure of these circuits in the whole brain is not entirely clear. Here, combining viral tracing with fluorescent micro-optical sectional tomography, we comprehensively investigated the input and output circuits of two cholinergic subregions in a continuous whole-brain dataset. We found that these nuclei receive abundant input with similar spatial distributions but with different quantitative measures and acquire similar neuromodulatory afferents from the ascending reticular activation system. Meanwhile, these cholinergic nuclei project to similar targeting areas throughout multiple brai

SUBMITTER: Zhao P 

PROVIDER: S-EPMC9152021 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature