Sex-Specific Neural Networks of Cued Threat Conditioning: A Pilot Study.

ABSTRACT: Cued threat conditioning is the most common preclinical model for emotional memory, which is dysregulated in anxiety disorders and post-traumatic stress disorder. Though women are twice as likely as men to develop these disorders, current knowledge of threat conditioning networks was established by studies that excluded female subjects. For unbiased investigation of sex differences in these networks, we quantified the neural activity marker c-fos across 112 brain regions in adult male and female mice after cued threat conditioning compared to naïve controls. We found that trained females engaged prelimbic cortex, lateral amygdala, cortical amygdala, dorsal peduncular cortex, and subparafasicular nucleus more than, and subparaventricular zone less than, trained males. To explore how these s

SUBMITTER: du Plessis KC 

PROVIDER: S-EPMC9152023 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature