Plasma miR-153 and miR-223 Levels as Potential Biomarkers in Parkinson's Disease.

ABSTRACT:

Background

Small molecule RNAs (miRNAs) could induce downregulation of α-synuclein (SNCA) expression by binding the 3' untranslated region of SNCA, thus playing an important role in the pathogenesis of Parkinson's disease (PD). Recent studies suggest that SNCA-related miRNAs in saliva are promising PD biomarkers. Research on those miRNAs in plasma is rare in patients with PD.

Objective

To detect the plasma expression levels of three SNCA related miRNAs (miR-7, miR-153, and miR-223) in PD, and to explore their diagnostic value and associations with clinical phenotype.

Methods

MiR-7, miR-153, and miR-223 levels were detected in the plasma of 75 PD patients and 73 normal controls (NCs) via real-time quantitative polymerase chain reaction. The receiver operating ch

SUBMITTER: Wu L 

PROVIDER: S-EPMC9152100 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature