The utility of cfDNA in TGCT patient management: a systematic review.

ABSTRACT:

Background

Testicular germ cell tumors (TGCTs) are the most common young male malignancy with a steadily rising incidence. Standard clinical practice is radical orchidectomy of suspicious lumps followed by histopathological diagnosis and tumor subtyping. This practice can lead to complications and quality of life issues for the patients. Liquid biopsies, especially cell-free DNA (cfDNA), promised to be true surrogates for tissue biopsies, which are considered dangerous to perform in cases of testicular tumors. In this study, we have performed a systematic review on the potential of cfDNA in TGCT patient management, its potential challenges in translation to clinical application and possible approaches in further research.

Materials & methods

The review was performed accordin

SUBMITTER: Krasic J 

PROVIDER: S-EPMC9152191 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature