Sleep and Late-Onset Alzheimer's Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects.

ABSTRACT: Late-onset Alzheimer's disease (AD) is associated with sleep-related phenotypes (SRPs). The fact that whether they share a common genetic etiology remains largely unknown. We explored the shared genetics and causality between AD and SRPs by using high-definition likelihood (HDL), cross-phenotype association study (CPASSOC), transcriptome-wide association study (TWAS), and bidirectional Mendelian randomization (MR) in summary-level data for AD (N = 455,258) and summary-level data for seven SRPs (sample size ranges from 359,916 to 1,331,010). AD shared a strong genetic basis with insomnia (r _g = 0.20; p = 9.70 × 10^-5), snoring (r _g = 0.13; p = 2.45 × 10^-3), and sleep duration (r _g = -0.11; p</

SUBMITTER: Chen D 

PROVIDER: S-EPMC9152224 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature