Plasma Membrane Localization of CD36 Requires Vimentin Phosphorylation; A Mechanism by Which Macrophage Vimentin Promotes Atherosclerosis.

ABSTRACT: Vimentin is a type III intermediate filament protein expressed in cells of mesenchymal origin. Vimentin has been thought to function mainly as a structural protein and roles of vimentin in other cellular processes have not been extensively studied. Our current study aims to reveal functions of vimentin in macrophage foam cell formation, the critical stage of atherosclerosis. We demonstrated that vimentin null (Vim ^{-/ -} ) mouse peritoneal macrophages take up less oxidized LDL (oxLDL) than vimentin wild type (Vim ^+/+) macrophages. Despite less uptake of oxLDL in Vim ^{-/ -} macrophages, Vim ^+/+ and Vim ^{-/ -} macrophages did not show differe

SUBMITTER: Kim SY 

PROVIDER: S-EPMC9152264 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature