Efficient Simulation of 3D Reaction-Diffusion in Models of Neurons and Networks.

ABSTRACT: Neuronal activity is the result of both the electrophysiology and chemophysiology. A neuron can be well-represented for the purposes of electrophysiological simulation as a tree composed of connected cylinders. This representation is also apt for 1D simulations of their chemophysiology, provided the spatial scale is larger than the diameter of the cylinders and there is radial symmetry. Higher dimensional simulation is necessary to accurately capture the dynamics when these criteria are not met, such as with wave curvature, spines, or diffusion near the soma. We have developed a solution to enable efficient finite volume method simulation of reaction-diffusion kinetics in intracellular 3D regions in neuron and network models and provide an implementation within the NEURON simulator. An acc

SUBMITTER: McDougal RA 

PROVIDER: S-EPMC9152282 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature