"Alterations in the Skin Microbiota Are Associated With Symptom Severity in Mycosis Fungoides".

ABSTRACT: Cutaneous T cell lymphoma (CTCL), a non-Hodgkin lymphoma, is thought to arise from mature tissue-resident memory T cells. The most common subtypes include Mycosis Fungoides and Sezary Syndrome. The role of skin microbiota remains unclear in the symptom manifestation of MF. Among 39 patients with MF, we analyzed bacteria colonizing MF lesions and non-lesional skin in the contralateral side and characterized regional changes in the skin microbiota related to MF involvement using the difference in relative abundance of each genus between lesional and contralateral non-lesional skin. We investigated the relationship between these skin microbiota alterations and symptom severity. No statistically significant difference was found in bacterial diversity and richness between lesional and non-lesio

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9152451 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature