Treatment of hyperglycemia not associated with NAFLD improvement in children with type 2 diabetes mellitus

ABSTRACT:

Background and objectives

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) have become public health problems in the pediatric population. However, the relationship between these two conditions is not well understood. The primary objective of this study was to assess whether treatment of hyperglycemia in obese, treatment-naive children with type 2 diabetes (T2DM) was associated with an improvement of surrogate markers of NAFLD.

Materials and methods

This retrospective, longitudinal study included 151 obese children with a diagnosis of T2DM (Age: 14 ± 1 years, 72% female children, BMI: 98.6th percentile, and A1c: 10.3 ± 0.2%). Clinical/demographic information was collected before patients started any diabetes treatment and 1 and 3 years after st

SUBMITTER: Beauchamp G 

PROVIDER: S-EPMC9152559 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature