High-resolution analysis of long-term serum antibodies in humans following convalescence of SARS-CoV-2 infection.

ABSTRACT: Long-term antibody responses to SARS-CoV-2 have focused on responses to full-length spike protein, specific domains within spike, or nucleoprotein. In this study, we used high-density peptide microarrays representing the complete proteome of SARS-CoV-2 to identify binding sites (epitopes) targeted by antibodies present in the blood of COVID-19 resolved cases at 5 months post-diagnosis. Compared to previous studies that evaluated epitope-specific responses early post-diagnosis (< 60 days), we found that epitope-specific responses to nucleoprotein and spike protein have contracted, and that responses to membrane protein have expanded. Although antibody titers to full-length spike and nucleoprotein remain steady over months, taken together our data suggest that the population of epitope-speci

SUBMITTER: Facciuolo A 

PROVIDER: S-EPMC9152668 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature