Early Whole-Body Diffusion-weighted MRI Helps Predict Long-term Outcome Following Peptide Receptor Radionuclide Therapy for Metastatic Neuroendocrine Tumors.

ABSTRACT: Purpose To evaluate the predictive value of 7-week apparent diffusion coefficient change from baseline (ADCratio_7w) at whole-body diffusion-weighted MRI (WB-DWI MRI) after one peptide receptor radionuclide therapy (PRRT) cycle to predict outcome in patients with metastatic neuroendocrine tumor (mNET). Materials and Methods From April 2009 to May 2012, participants in a prospective clinical trial investigating yttrium 90-DOTA Phe1-Tyr³-octreotide (DOTATOC) treatment for mNET (EudraCT no. 2008-007965-22) underwent WB-DWI MRI and gallium 68 (⁶⁸Ga)-DOTATOC PET/CT before and 7 weeks after one PRRT cycle. ADCratio_7w response was compared with the 7-week Response Evaluation Criteria in Solid Tumors version 1.1 and ⁶⁸Ga-DOTATOC PET/CT quantita

SUBMITTER: Vandecaveye V 

PROVIDER: S-EPMC9152691 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature