Interobserver Variability in CT-based Morphologic Tumor Response Assessment of Colorectal Liver Metastases.

ABSTRACT: Purpose To evaluate interobserver variability in the morphologic tumor response assessment of colorectal liver metastases (CRLM) managed with systemic therapy and to assess the relation of morphologic response with gene mutation status, targeted therapy, and Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 measurements. Materials and Methods Participants with initially unresectable CRLM receiving different systemic therapy regimens from the randomized, controlled CAIRO5 trial (NCT02162563) were included in this prospective imaging study. Three radiologists independently assessed morphologic tumor response on baseline and first follow-up CT scans according to previously published criteria. Two additional radiologists evaluated disagreement cases. Interobserver agreement was

SUBMITTER: Wesdorp NJ 

PROVIDER: S-EPMC9152692 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature