Toxicant exposure during pregnancy increases protective proteins in the dam and a sexually dimorphic response in the fetus.

ABSTRACT: Endocrine disrupting compounds (EDCs) are ubiquitous environmental pollutants that alter endocrine system function, induce birth defects, and a myriad of other negative health outcomes. Although the mechanism of toxicity of many EDCs have been studied in detail, little work has focused on understanding the mechanisms through which pregnant dams and fetuses protect themselves from EDCs, or if those protective mechanisms are sexually dimorphic in fetuses. In this study, we examined proteomic alterations in the livers of mouse dams and their male and female fetuses induced by vinclozolin, a model antiandrogenic EDC. Dam livers upregulated nine phase I and phase II detoxification pathways and pathway analysis revealed that more pathways are significantly enriched in dam livers than in fetal li

SUBMITTER: Rister AL 

PROVIDER: S-EPMC9152768 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature