Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model.

ABSTRACT: Primary or secondary immunodeficiencies are characterized by disruption of cellular and humoral immunity. Respiratory infections are a major cause of morbidity and mortality among immunodeficient or immunocompromised patients, with Staphylococcus aureus being a common offending organism. We propose here an adoptive macrophage transfer approach aiming to enhance impaired pulmonary immunity against S aureus. Our studies, using human-induced pluripotent stem cell-derived macrophages (iMφs), demonstrate efficient antimicrobial potential against methicillin-sensitive and methicillin-resistant clinical isolates of S aureus. Using an S aureus airway infection model in immunodeficient mice, we demonstrate that the adoptive transfer of iMφs is able to reduce the bacterial load more than 10-fold wit

SUBMITTER: Rafiei Hashtchin A 

PROVIDER: S-EPMC9153022 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature