Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics.

ABSTRACT: Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized by increased sialic acid, a greater negative charge, and decreased activity compared with adults. Despite these differences, adult fibrinogen is used for the treatment of bleeding in neonates, with mixed efficacy. To determine safe and efficacious bleeding protocols for neonates, more information on neonatal fibrin clot formation and the influence of sialic acid on these processes is needed. Here, we examine the influence of sialic acid on neonatal fibrin polymerization. We hypothesized that the increased sialic acid content of neonatal fibrinogen promotes fibrin B:b knob-hole interactions and consequently influences the structure and function of the neonatal fibrin matrix. We explored this hypothe

SUBMITTER: Nellenbach K 

PROVIDER: S-EPMC9153052 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature