Cucurbituril-Ferrocene: Host-Guest Based Pretargeted Positron Emission Tomography in a Xenograft Model.

ABSTRACT: Pretargeted positron emission tomography is a macromolecule-driven nuclear medicine technique that involves targeting a preadministered antigen target-bound macromolecule with a radioligand in vivo, aiming to minimize the overall radiation dose. This study investigates the use of antibody based host-guest chemistry methodology for pretargeted positron emission tomography. We hypothesize that the novel pretargeting approach reported here overcomes the challenges the current pretargeting platforms have with the in vivo stability and modularity of the pretargeting components. A cucurbit[7]uril host molecule modified, anti-carcinoembryonic antigen antibody (M5A; CB7-M5A) and a ⁶⁸Ga-radiolabeled ferrocene guest radioligand ([⁶⁸Ga]Ga-NOTA-PEG₃-NMe

SUBMITTER: Jallinoja VIJ 

PROVIDER: S-EPMC9153067 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature