Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila.

ABSTRACT: Individual hosts within populations often show inter-individual variation in their susceptibility to bacterial pathogen-related diseases. Utilizing Drosophila, we highlight that phenotypic variation in host-pathogen susceptibility within populations is driven by energetic trade-offs, facilitated by infection-mediated changes in glutamate metabolism. Furthermore, host-pathogen susceptibility is conditioned by life history, which adjusts immunometabolic sensing in muscles to direct vitamin-dependent reallocation of host energy substrates from the adipose tissue (i.e., a muscle-adipose tissue axis). Life history conditions inter-individual variation in the activation strength of intra-muscular NF-κB signaling. Limited intra-muscular NF-κB signaling activity allows for enhanced infection-media

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9153082 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature