The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential.

ABSTRACT:

Background

Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role for disrupted epigenetic regulation of normal brain development in tumorigenesis. For example, lysine 27 to methionine mutation (H3K27M) in the H3F3A gene occurs frequently in Diffuse Intrinsic Pontine Gliomas (DIPGs), the most aggressive pediatric glioma. As H3K27M mutation is necessary but insufficient to cause DIPGs, it is accompanied by additional mutations in tumors. However, how H3K27M alone increases vulnerability to DIPG tumorigenesis remains unclear.

Results

Here, we used human embryonic stem cell models with this mut

SUBMITTER: Kfoury-Beaumont N 

PROVIDER: S-EPMC9153095 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature