Quantifying shifts in natural selection on codon usage between protein regions: a population genetics approach.

ABSTRACT:

Background

Codon usage bias (CUB), the non-uniform usage of synonymous codons, occurs across all domains of life. Adaptive CUB is hypothesized to result from various selective pressures, including selection for efficient ribosome elongation, accurate translation, mRNA secondary structure, and/or protein folding. Given the critical link between protein folding and protein function, numerous studies have analyzed the relationship between codon usage and protein structure. The results from these studies have often been contradictory, likely reflecting the differing methods used for measuring codon usage and the failure to appropriately control for confounding factors, such as differences in amino acid usage between protein structures and changes in the frequency of different structure

SUBMITTER: Cope AL 

PROVIDER: S-EPMC9153123 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature