Association of elevated plasma inflammatory biomarker levels with age-related macular degeneration but not cataract in persons with AIDS.

ABSTRACT:

Objective

To evaluate the relationship between plasma biomarkers of systemic inflammation and incident age-related macular degeneration (AMD) in persons with the AIDS.

Design

Case-control study.

Methods

Participants with incident intermediate-stage AMD (N = 26) in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) and controls (N = 60) without AMD. Cryopreserved baseline plasma specimens were assayed for biomarkers of inflammation, including high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, interferon-γ inducible protein (IP)-10, soluble CD14 (sCD14), soluble CD163 (sCD163), and intestinal fatty acid-binding protein (I-FABP).

Results

After adjustment for age, sex, and race/ethnicity, baseline mean ± standard deviation (SD) log10(mg/

SUBMITTER: Jabs DA 

PROVIDER: S-EPMC9153135 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature