Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans.

ABSTRACT:

Background

Bone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in several age-related diseases including cancer, Alzheimer's disease, obesity, and cardiovascular disease. Aberrant BMP signaling in mice leads to obesity, suggesting it may alter normal metabolism. The role of BMP signaling regulating cancer metabolism is not known.

Methods

To examine BMP regulation of metabolism, C. elegans harboring BMP gain-of-function (gof) and loss-of-function (lof) mutations were examined for changes in activity of catabolic and anabolic metabolism utilizing Western blot analysis and fluorescent reporters. AMP activated kinase (AMPK) gof and lof mutants were used to examine AMPK regulation of BMP signalin

SUBMITTER: Vora M 

PROVIDER: S-EPMC9153151 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature