Genetic support of a causal relationship between iron status and atrial fibrillation: a Mendelian randomization study.

ABSTRACT:

Background

Atrial fibrillation is the most common arrhythmia disease. Animal and observational studies have found a link between iron status and atrial fibrillation. However, the causal relationship between iron status and AF remains unclear. The purpose of this investigation was to use Mendelian randomization (MR) analysis, which has been widely applied to estimate the causal effect, to reveal whether systemic iron status was causally related to atrial fibrillation.

Methods

Single nucleotide polymorphisms (SNPs) strongly associated (P < 5 × 10^-8) with four biomarkers of systemic iron status were obtained from a genome-wide association study involving 48,972 subjects conducted by the Genetics of Iron Status consortium. Summary-level data for the genetic associatio

SUBMITTER: Wang T 

PROVIDER: S-EPMC9153204 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature