Moderators of subjective response to alcohol in the human laboratory.

ABSTRACT:

Background

Subjective response (SR) to alcohol represents a biobehavioral risk factor for heavy drinking and for developing alcohol use disorder (AUD). Identifying moderators of SR have been hindered by small sample sizes that are often used in alcohol administration studies.

Methods

This study combined data from multiple alcohol administration trials to test whether sex, family history of alcohol problems, and impulsivity (via delay discounting) predict SR to alcohol, comprised of four domains: stimulation, sedation, negative affect, and craving. Non-treatment-seeking heavy drinkers (N = 250) completed a battery of self-report scales and behavioral measures of alcohol use and problems, mood, and impulsivity. All participants completed an intravenous alcohol administration s

SUBMITTER: Nieto SJ 

PROVIDER: S-EPMC9153269 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature