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Molecular innovations in plant TIR-based immunity signaling.

ABSTRACT: A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of TIR evolution and the molecular versatility of TIR domains in different protein architectures for host protection against microbial attack. Plant TIR-based signaling emerges as being central to the potentiation and effectiveness of host defenses triggered by intracellular and cell-surface immune receptors. Equally relevant for plant fitness are mechanisms that limit potent TIR signaling in healthy tissues but maintain preparedness for infection. We propose that seed plants evolved a specialized protein module to selectively translate TIR enzymatic activities to defense outputs, overlaying a more general function of TIRs.

SUBMITTER: Lapin D

PROVIDER: S-EPMC9153377 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Molecular innovations in plant TIR-based immunity signaling.

Lapin Dmitry D Johanndrees Oliver O Wu Zhongshou Z Li Xin X Parker Jane E JE

The Plant cell 20220401 5

A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of TIR evolution and the molecular versatility of TIR domains in different protein architectures for host protection against microbial attack. Plant TIR-based signaling emerges as being central to the potentiation and effectiveness of host defenses triggered by intracellular and cell-surface immune receptors. Equally rele ...[more]

PMID: 35143666

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