Identification of Significant Secreted or Membrane-Located Proteins in Laryngeal Squamous Cell Carcinoma.

ABSTRACT:

Background

This study is aimed at investigating the expressions and prognostic values of secreted or membrane-located proteins (SMPs) in laryngeal squamous cell carcinoma (LSCC). The correlations between the expressions of SMPs and immune cells' infiltrations were also investigated.

Methods

The expression data of normal laryngeal and LSCC samples were obtained from the TCGA and GEO datasets. The differentially expressed SMPs were identified, and their prognostic values were analyzed. The biological functions of differentially expressed and worse-survival-related SMPs were explored. LASSO regression, Cox multivariate analysis, and nomogram were used to construct a model to predict the survival. Then, the infiltrations of the 24 immune cell populations were calculated using th

SUBMITTER: Yan L 

PROVIDER: S-EPMC9153386 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature