Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis.

ABSTRACT:

Background

Angiogenesis is a dynamic process that involves expansion of a preexisting vascular network that can occur in a number of physiological and pathological settings. Despite its importance, the origin of the new angiogenic vasculature is poorly defined. In particular, the primary subtype of endothelial cells (capillary, venous, arterial) driving this process remains undefined.

Methods

Endothelial cells were fate-mapped with the use of genetic markers specific to arterial and capillary cells. In addition, we identified a novel venous endothelial marker gene (Gm5127) and used it to generate inducible venous endothelium-specific Cre and Dre driver mouse lines. Contributions of these various types of endothelial cells to angiogenesis were examined during normal po

SUBMITTER: Lee HW 

PROVIDER: S-EPMC9153651 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature