Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes.

ABSTRACT:

Aims/introduction

We aimed to study the predictive ability of visit-to-visit variability in albuminuria for changes in renal function in patients with type 2 diabetes mellitus.

Materials and methods

The cohort study was carried out in a single medical center. In the model development cohort of 1008 subjects, we developed the albuminuria variability score (AVS) to evaluate the visit-to-visit variability in albuminuria, which was the percentage of the number of changes in the urine albumin : creatinine ratio ≥3.39 mg/mmol among all visit-to-visit urine albumin : creatinine ratio differences within an individual. Multivariate logistic regression was applied to predict the influence of AVS levels on the occurrence of study end-points. In another independent validation cohort of

SUBMITTER: Lin CH 

PROVIDER: S-EPMC9153848 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature