Maternal diabetes independent of BMI is associated with altered accretion of adipose tissue in large for gestational age fetuses.

ABSTRACT:

Aim

To analyse the effects of maternal diabetes mellitus (DM) and body mass Index (BMI) on central and peripheral fat accretion of large for gestational age (LGA) offspring.

Methods

This retrospective study included LGA fetuses (n = 595) with ultrasound scans at early (19.23 ± 0.68 weeks), mid (28.98 ± 1.62 weeks) and late (36.20 ± 1.59 weeks) stages of adipogenesis and measured abdominal (AFT) and mid-thigh (TFT) fat as surrogates for central and peripheral adiposity. Women were categorised according to BMI and DM status [pre-gestational (P-DM; n = 59), insulin managed (I-GDM; n = 132) and diet managed gestational diabetes (D-GDM; n = 29)]. Analysis of variance and linear regressions were applied.

Results

AFT and TFT did not differ significantly between BMI categorie

SUBMITTER: Lam P 

PROVIDER: S-EPMC9154097 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature