Citicoline in acute ischemic stroke: A randomized controlled trial.

ABSTRACT:

Introduction

Two pharmacological possibilities exist for an acute ischemic stroke (AIS): recanalization of the occluded artery and neuroprotection from ischaemic injury, the latter's efficacy being debatable. We sought to determine whether administration of Citicoline immediately after recanalization therapy for AIS would improve clinical and radiological outcome at three months compared to standard treatment alone.

Patients and methods

CAISR was a single centre, randomized, placebo-controlled, parallel-group trial with blinded endpoint assessment. It was approved by the All India Institute of Medical Sciences Institutional ethics committee and registered at the Clinical Trial Registry of India (CTRI/2018/011900). We recruited participants with AIS undergoing recanalization

SUBMITTER: Agarwal A 

PROVIDER: S-EPMC9154187 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature