Short-Term Fasting Attenuates Overall Steroid Hormone Biosynthesis in Healthy Young Women.

ABSTRACT:

Context

Fasting is stressful for the human body. It is managed by metabolic adaptations maintaining energy homeostasis and involves steroid hormone biosynthesis, but the exact interplay between energy and steroid metabolism remains elusive. Women with polycystic ovary syndrome (PCOS) suffer from disturbed metabolism and androgen excess, while in women with anorexia nervosa, cortisol and androgen production are decreased. By contrast, starvation of steroidogenic cells shifts adrenal steroid biosynthesis toward enhanced androgen production.

Aim

This study investigated the effect of fasting on steroid production in healthy women.

Methods

Twenty healthy young women fasted for 48 hours; steroid profiles from plasma and urine samples were assessed at baseline, after 24 hour

SUBMITTER: Magyar BP 

PROVIDER: S-EPMC9154271 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature