The ENDS of assumptions: an online tool for the epistemic non-parametric drug-response scoring.

ABSTRACT:

Motivation

The drug sensitivity analysis is often elucidated from drug dose-response curves. These curves capture the degree of cell viability (or inhibition) over a range of induced drugs, often with parametric assumptions that are rarely validated.

Results

We present a class of non-parametric models for the curve fitting and scoring of drug dose-responses. To allow a more objective representation of the drug sensitivity, these epistemic models devoid of any parametric assumptions attached to the linear fit, allow the parallel indexing such as half-maximal inhibitory concentration and area under curve. Specifically, three non-parametric models including spline (npS), monotonic and Bayesian and the parametric logistic are implemented. Other indices including maximum effectiv

SUBMITTER: Amiryousefi A 

PROVIDER: S-EPMC9154283 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature