A Model of Human Small Airway on a Chip for Studies of Subacute Effects of Inhalation Toxicants.

ABSTRACT: Testing for acute inhalation hazards is conducted in animals; however, a number of robust in vitro human cell-based alternatives have been developed and tested. These models range in complexity from cultures of cell lines or primary cells in air-liquid interface on Transwells, to more complex and physiologically relevant flow- and mechanical stimulation-enabled tissue chips. Although the former models are relatively straightforward to establish and can be tested in medium/high throughput, the latter require specialized equipment and lack in throughput. In this study, we developed a device that can be easily manufactured while allowing for the production of a differentiated lung tissue. This multilayered microfluidic device enables coculture of primary human small airway epithelial cells an

SUBMITTER: Sakolish C 

PROVIDER: S-EPMC9154286 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature