Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data.

ABSTRACT:

Background

Pineoblastoma is a rare brain tumor usually diagnosed in children. Given its rarity, no pineoblastoma-specific trials have been conducted. Studies have included pineoblastoma accruing for other embryonal tumors over the past 30 years. These included only occasional children with pineoblastoma, making clinical features difficult to interpret and determinants of outcome difficult to ascertain.

Patients and methods

Centrally or independently reviewed series with treatment and survival data from North American and Australian cases were pooled. To investigate associations between variables, Fisher's exact tests, Wilcoxon-Mann-Whitney tests, and Spearman correlations were used. Kaplan-Meier plots, log-rank tests, and Cox proportional hazards models were used in survival

SUBMITTER: Hansford JR 

PROVIDER: S-EPMC9154333 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature