Cellular prion protein distribution in the vomeronasal organ, parotid, and scent glands of white-tailed deer and mule deer.

ABSTRACT: Chronic wasting disease (CWD) is a contagious and fatal transmissible spongiform encephalopathy affecting species of the cervidae family. CWD has an expanding geographic range and complex, poorly understood transmission mechanics. CWD is disproportionately prevalent in wild male mule deer and male white-tailed deer. Sex and species influences on CWD prevalence have been hypothesized to be related to animal behaviours that involve deer facial and body exocrine glands. Understanding CWD transmission potential requires a foundational knowledge of the cellular prion protein (PrP^C) in glands associated with cervid behaviours. In this study, we characterized the presence and distribution of PrP^C in six integumentary and two non-integumentary tissues of hunter-harvested mule

SUBMITTER: Ness A 

PROVIDER: S-EPMC9154781 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature