N6-methyladenosine-modified RNA acts as a molecular glue that drives liquid-liquid phase separation in plants.
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ABSTRACT:
SUBMITTER: Lee HG
PROVIDER: S-EPMC9154792 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
N<sup>6</sup>-methyladenosine-modified RNA acts as a molecular glue that drives liquid-liquid phase separation in plants.
Lee Hong Gil HG Kim Jiwoo J Seo Pil Joon PJ
Plant signaling & behavior 20221201 1
Liquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N<sup>6</sup>-methyladenosine (m<sup>6</sup>A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m<sup>6</sup>A-reader proteins contain putative prion-like domains, and the <i>ect2/3/4</i> mutant exhibited reduced formation of key nuclear and cytoplasmic condensates in <i>Arabidopsis</i>. ...[more]
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