Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy.

ABSTRACT: The past decades witnessed the clinical employment of targeted therapies including but not limited to tyrosine kinase inhibitors (TKIs) that restrain a broad variety of pro-tumorigenic signals. TKIs can be categorized into (i) agents that directly target cancer cells, (ii) normalize angiogenesis or (iii) affect cells of the hematologic lineage. However, a clear distinction of TKIs based on this definition is limited by the fact that many TKIs designed to inhibit cancer cells have also effects on immune cells that are being discovered. Additionally, TKIs originally designed to target hematological cancers exhibit bioactivities on healthy cells of the same hematological lineage. TKIs have been described to improve immune recognition and cancer immunosurveillance, providing the scientific bas

SUBMITTER: Petrazzuolo A 

PROVIDER: S-EPMC9154809 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature