J-shaped associations and joint effects of fasting glucose with inflammation and cytokines on COVID-19 mortality.

ABSTRACT:

Objectives

The aim of this study was to investigate the dose-response relationship of admission fasting glucose (FBG) with corona virus disease 2019 (COVID-19) mortality and to further evaluate potential interactions of hyperglycemia with inflammation and hypercoagulation on COVID-19 outcomes.

Methods

This retrospective study included 2555 consecutively hospitalized patients with COVID-19, until death or discharge, in Wuhan Union hospital between January 1 and April 9, 2020. The poor early outcomes included admission to intensive care unit, intubation, and deaths occurring within 28 days. We used splines nested in Cox regression to visualize dose-response associations and generalized additive models to fit three-dimensional (3D) trend plots for joint effects of FBG with mark

SUBMITTER: Lai X 

PROVIDER: S-EPMC9155189 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature