Modern venomics-Current insights, novel methods, and future perspectives in biological and applied animal venom research.

ABSTRACT: Venoms have evolved >100 times in all major animal groups, and their components, known as toxins, have been fine-tuned over millions of years into highly effective biochemical weapons. There are many outstanding questions on the evolution of toxin arsenals, such as how venom genes originate, how venom contributes to the fitness of venomous species, and which modifications at the genomic, transcriptomic, and protein level drive their evolution. These questions have received particularly little attention outside of snakes, cone snails, spiders, and scorpions. Venom compounds have further become a source of inspiration for translational research using their diverse bioactivities for various applications. We highlight here recent advances and new strategies in modern venomics and discuss how r

SUBMITTER: von Reumont BM 

PROVIDER: S-EPMC9155608 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature