Drug concentration at the site of disease in children with pulmonary tuberculosis.

ABSTRACT:

Background

Current TB treatment for children is not optimized to provide adequate drug levels in TB lesions. Dose optimization of first-line antituberculosis drugs to increase exposure at the site of disease could facilitate more optimal treatment and future treatment-shortening strategies across the disease spectrum in children with pulmonary TB.

Objectives

To determine the concentrations of first-line antituberculosis drugs at the site of disease in children with intrathoracic TB.

Methods

We quantified drug concentrations in tissue samples from 13 children, median age 8.6 months, with complicated forms of pulmonary TB requiring bronchoscopy or transthoracic surgical lymph node decompression in a tertiary hospital in Cape Town, South Africa. Pharmacokinetic models we

SUBMITTER: Lopez-Varela E 

PROVIDER: S-EPMC9155609 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature