Bioinformatics Study Identified EGF as a Crucial Gene in Papillary Renal Cell Cancer.

ABSTRACT:

Background

Due to a lack of knowledge of the disease process, papillary renal cell carcinoma (PRCC) has a dismal outlook. This research was aimed at uncovering the possible biomarkers and the underlying principles in PRCC using a bioinformatics method.

Methods

We searched the Gene Expression Omnibus (GEO) datasets to obtain the GSE11151 and GSE15641 gene expression profiles of PRCC. We used the R package limma to identify the differentially expressed genes (DEGs). The online tool DAVID and ClusterProfiler package in R software were used to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway dominance, respectively. The STRING database was utilized to construct the PPI network of DEGs. Using the Cytoscape technology, a protein-protein interaction

SUBMITTER: Qu G 

PROVIDER: S-EPMC9155928 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature