Coupling cognitive and brainstem dysfunction in multiple sclerosis-related chronic neuropathic limb pain.

ABSTRACT: Chronic pain in multiple sclerosis is common and difficult to treat. Its mechanisms remain incompletely understood. Dysfunction of the descending pain modulatory system is known to contribute to human chronic pain conditions. However, it is not clear how alterations in executive function influence this network, despite healthy volunteer studies linking function of the descending pain modulatory system, to cognition. In adults with multiple sclerosis-associated chronic neuropathic limb pain, compared to those without pain, we hypothesized altered functional connectivity of the descending pain modulatory system, coupled to executive dysfunction. Specifically we hypothesized reduced mental flexibility, because of potential importance in stimulus reappraisal. To investigate these hypotheses, w

SUBMITTER: Foley P 

PROVIDER: S-EPMC9155950 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature