Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors.

ABSTRACT:

Aims

To explore the expression of circular RNA (circRNA) in gastrointestinal stromal tumors.

Background

Gastrointestinal stromal tumors (GIST) are mainly distributed in the stomach and small intestine. Recently, it has been verified that circular RNA (circRNA) has an important function in the regulation of GIST. Nevertheless, detailed investigations of circRNA-miRNA-mRNA regulatory networks in GIST are lacking.

Objective

To analyze the gastrointestinal stromal tumor circRNA-miRNA-mRNA network, assessing the effect of circle RNA in gastrointestinal stromal tumors.

Method

All the differential circRNAs and mRNAs were obtained from Gene Expression Omnibus (GEO) microarray data (GSE131481 and GSE147303, GSE131481, and GSE13861). Furthermore, a circRNA-miRNA-mRNA net

SUBMITTER: Chunyan-Zou 

PROVIDER: S-EPMC9155966 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature