Dataset Information

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.

ABSTRACT:

Aims

Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome).

Methods and results

FINGER enrolled 1259 individuals aged 60-77 years (ClinicalTrials.gov NCT01041989). They were randomized (1:1) to a 2-year multi-domain intervention with diet, physical and cognitive activity, and vascular monitoring (n = 631), or general health advice (n = 628). National registries provided data on CVD including stroke, transient ischaemic attack (TIA), or coronary heart event. During an average of 7.4 years, 229 participants (18%) had at least one CVD diagnosis: 107 in the intervention group and 122 in the control group. The incidence of cerebrovascular events was lower in the intervention than the control group: hazard ratio (HR) for combined stroke/TIA was 0.71 [95% confidence interval (CI): 0.51-0.99] after adjusting for background characteristics. Hazard ratio for coronary events was 0.84 (CI: 0.56-1.26) and total CVD events 0.80 (95% CI: 0.61-1.04). Among those with history of CVD (n = 145), the incidence of both total CVD events (HR: 0.50, 95% CI: 0.28-0.90) and stroke/TIA (HR: 0.40, 95% CI: 0.20-0.81) was lower in the intervention than the control group.

Conclusion

A 2-year multi-domain lifestyle intervention among older adults was effective in preventing cerebrovascular events and also total CVD events among those who had history of CVD.

SUBMITTER: Lehtisalo J

PROVIDER: S-EPMC9156384 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.

Lehtisalo Jenni J Rusanen Minna M Solomon Alina A Antikainen Riitta R Laatikainen Tiina T Peltonen Markku M Strandberg Timo T Tuomilehto Jaakko J Soininen Hilkka H Kivipelto Miia M Ngandu Tiia T

European heart journal 20220601 21

<h4>Aims</h4>Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome).<h4>Methods and results</h4>FINGER enrolled 1259 individuals aged 60-77 years (ClinicalTrials.gov NCT01041989). ...[more]

PMID: 35051281

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Dataset Information

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.

Aims

Methods and results

Conclusion

Publications

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.

Similar Datasets

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