Trigeminal neurons control immune-bone cell interaction and metabolism in apical periodontitis.

ABSTRACT: Apical periodontitis (AP) is an inflammatory disease occurring following tooth infection with distinct osteolytic activity. Despite increasing evidence that sensory neurons participate in regulation of non-neuronal cells, their role in the development of AP is largely unknown. We hypothesized that trigeminal ganglia (TG) Nav1.8⁺ nociceptors regulate bone metabolism changes in response to AP. A selective ablation of nociceptive neurons in Nav1.8^Cre/Diphtheria toxin A (DTA)^Lox mouse line was used to evaluate the development and progression of AP using murine model of infection-induced AP. Ablation of Nav1.8⁺ nociceptors had earlier progression of AP with larger osteolytic lesions. Immunohistochemical and RNAscope analyses demonstrated greater numbe

SUBMITTER: Austah ON 

PROVIDER: S-EPMC9156470 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature