Rheumatoid Factor and Anti-Modified Protein Antibody Reactivities Converge on IgG Epitopes.

ABSTRACT:

Objective

Rheumatoid arthritis (RA) patients often develop rheumatoid factors (RFs), antibodies that bind IgG Fc, and anti-modified protein antibodies (AMPAs), multireactive autoantibodies that commonly bind citrullinated, homocitrullinated, and acetylated antigens. Recently, antibodies that bind citrulline-containing IgG epitopes were discovered in RA, suggesting that additional undiscovered IgG epitopes could exist and that IgG could be a shared antigen for RFs and AMPAs. This study was undertaken to reveal new IgG epitopes in rheumatic disease and to determine if multireactive AMPAs bind IgG.

Methods

Using sera from patients with RA, systemic lupus erythematosus, Sjögren's disease (SjD), or spondyloarthropathy, IgG binding to native, citrulline-containing, and homocitrull

SUBMITTER: Mergaert AM 

PROVIDER: S-EPMC9156533 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature