Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice.

ABSTRACT: Gut microorganisms and the products of their metabolism thoroughly affect host brain development, function and behavior. Since alterations of brain plasticity and cognition have been demonstrated upon motor, sensorial and social enrichment of the housing conditions, we hypothesized that gut microbiota and metabolome could be altered by environmental stimuli, providing part of the missing link among environmental signals and brain effects. In this preliminary study, metagenomic and metabolomic analyses of mice housed in different environmental conditions, standard and enriched, identify environment-specific microbial communities and metabolic profiles. We show that mice housed in an enriched environment have distinctive microbiota composition with a reduction in gut bacterial richness and b

SUBMITTER: Marrocco F 

PROVIDER: S-EPMC9156677 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature