Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy.

ABSTRACT: In patients with diabetes, it has been suggested that physical exercise may reduce albuminuria and the progression of renal disease. However, the molecular mechanism by which physical exercise protects the kidney in diabetes remains poorly understood. The aim of the present study was to determine the contribution of muscle irisin secretion induced by aerobic physical exercise with the subsequent activation of AMPK for kidney protection under diabetic conditions. Aerobic physical exercise in rats protected the kidney in streptozotocin-induced diabetes. It reduced albuminuria, glomerular hypertrophy, and glomerular expression of collagen IV and fibronectin, as well as markers of kidney inflammation, when compared to sedentary diabetic rats. These effects were associated with elevation in mus

SUBMITTER: Formigari GP 

PROVIDER: S-EPMC9156698 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature