Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma.

ABSTRACT: The functional interdependence of nerves and blood vessels is a well-established concept during tissue morphogenesis, yet the role of neurovascular coupling in proper and aberrant tissue repair is an emerging field of interest. Here, we sought to define the regulatory relationship of peripheral nerves on vasculature in a severe extremity trauma model in mice, which results in aberrant cell fate and heterotopic ossification (HO). First, a high spatial degree of neurovascular congruency was observed to exist within extremity injury associated heterotopic ossification. Vascular and perivascular cells demonstrate characteristic responses to injury, as assessed by single cell RNA sequencing. This vascular response to injury was blunted in neurectomized mice, including a decrease in endothelial

SUBMITTER: Qin Q 

PROVIDER: S-EPMC9156761 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature